Will she or won’t she? That’s the big political question these days when it comes to whether U.S. Rep. Ayanna Pressley will run for U.S. Senate, challenging incumbent Ed Markey. The latest Suffolk/Globe poll suggests she can win a three-way Dem primary race against Markey and U.S. Rep. Seth Moulton. It would be a very close but doable race for an ambitious woman who got to where she is by knocking off a seemingly safe incumbent back in 2018. Personally, I can see my previously expressed Scenarios A.) and C.) unfolding, tilting more toward C.), if she indeed goes for it.

But that brings us back to the opening question: Will she or won’t she? I’d put the odds of her running at 40-60. She could gain a lot by running, but she’d be giving up a lot too, i.e. a very safe congressional seat. …

Passing thought: What is Alexandria Ocasio-Cortez thinking and advising? Markey is her progressive Green New Deal pal. But Pressley is her fellow Squad member. … Just wondering.

Passing thought II: What’s up with Gov. Healey’s numbers? She’s looking more vulnerable these days. 

Update — 11.30.25 –– From the Herald’s Joe Battenfeld: “Ayanna Pressley the looming bigfoot in U.S. Senate race”

Update II — 12.1.25 – The Herald’s Peter Lucas also thinks Pressley would be a formidable challenger to Markey — if she decides to challenge him.